Learn about Sonata (Zaleplon) may treat, uses, dosage, side effects, A study in lactating mothers indicated that the clearance and half-life of.
Skin and appendages -Frequent : pruritus, rash; Infrequent : acne, alopecia, contact dermatitis, dry skin, eczema, maculopapular rash, skin hypertrophy, sweating, urticaria, vesiculobullous rash; Rare : melanosis, psoriasis, pustular rash, skin discoloration.
10 mg: opaque green cap and opaque light green body with “10 mg” on the cap and “SONATA” on the body.
The structural formula is shown below. The chemical name of zaleplon is N-[3-(3-cyanopyrazolopyrimidin-7-yl)phenyl]-N-ethylacetamide.
Zaleplon AUC and elimination half-life were not significantly affected. These results suggest that the effects of Sonata on sleep onset may be reduced if it is taken.
Sonata 10 mg, but not 5 mg, was superior to placebo in decreasing latency to persistent sleep (LPS), a polysomnographic measure of time to onset of sleep. Normal adults experiencing transient insomnia during the first night in a sleep laboratory were evaluated in a double-blind, parallel-group trial comparing the effects of two doses of Sonata (5 mg and 10 mg) with placebo.
Gender: There is no significant difference in the pharmacokinetics of Sonata in men and women.
The pharmacokinetics of zaleplon have been investigated in more than 500 healthy subjects (young and elderly), nursing mothers, and patients with hepatic disease or renal disease.
Sonata is one of the fastest-acting sleeping pills available, with a terminal half-life of an hour. As such, Sonata is a prime target for accidental.
It can be difficult to l the difference between addictive and prescriptive use of the drug. Signs of a Sonata addiction can be hard for friends and family to spot. However, changes in behavior such as doctor shopping — acquiring multiple prescriptions for the drug — and using Sonata for any unprescribed purpose should be considered troubling.
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Side effects of Sonata abuse might include: Mental confusion Nausea and vomiting Amnesia Numbness or tingling Hallucinations Impaired coordination Aggression Headache Fatigue.
According to its label, “Sonata is indicated for the short-term treatment of insomnia. Sonata has been The half life of Sonata is approximay 1 hour. Sonata is.
TREATMENT. Sonata can be a very difficult drug to stop taking.
Sonata is mainly metabolized through the P450 pathway in the liver and the enzymes primarily handling the metabolism is CYP3A4 but it is not clear how much of the metabolism is done by other enzymes.
DESCRIPTION / DEFINITIONS. TREATMENT: Medical detoxification. WITHDRAWAL SYMPTOMS: Insomnia, anxiety (see list below).
Sonata is a Schedule IV Controlled Subtance. ABUSE: Sonata can have withdrawal symptoms.
ADDICTION / DEPENDENCE: Half Life and Metabolism.
HALF LIFE AND METABOLISM.
The biological half life of a substance is the time it takes for a drug to lose half of its pharmacologic activity.
Because Sonata is so short-lived in your body – called 'half-life – the drug is relatively useless for treating late insomnia or for patients who wake early in the wee.
Sonata provides a drug to the brain, stimulating a neurotransmitter, which acts as a gateway for sleep-inducing chemicals. Sonata allows your brain to introduce more of this natural sedative so you can go to sleep fast and get back into the sleep-wake cycle.
But there are some very good prescription sleep aids created specifically to combat insomnia. Sonata was developed to help insomnia sufferers suited to a relatively short-term treatment, kickstart their biological clocks. Insomnia is not a disorder but a set of symptoms that often are secondary to something else, such as depression or anxiety.