THIORIDAZINE HAS BEEN SHOWN TO PROLONG THE QTc INTERVAL IN A DOSE RELATED MANNER, AND DRUGS WITH THIS POTENTIAL, INCLUDING THIORIDAZINE, HAVE BEEN ASSOCIATED WITH TORSADE DE POINTES-TYPE ARRHYTHMIAS AND SUDDEN DEATH. Thioridazine hydrochloride is available as tablets for oral.
Dosage may be increased gradually until optimum therapeutic effect is obtained or the maximum dose of 3 mg/kg/ day has been reached. For pediatric patients with schizophrenia who are unresponsive to other agents, the recommended initial dose is 0.5 mg/kg/day given in divided doses.
They are available as follows:. The 25 mg tablets are orange, round, unscored, film-coated tablets debossed with M58 on one side and 25 on the other side.
C 21 H 26 N 2 S 2 •HCl..................M.Wt.: 407.05.
Pseudoparkinsonism and other extrapyramidal symptoms may occur but are infrequent.
Find patient medical information for Thioridazine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
l your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine ), anti- seizure drugs (e.g., phenytoin), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., chlorpromazine, risperidone, trazodone ).
Do not share this medication with others.
With WebMD's Medicine Cabinet, you can check interactions with drugs.
Seek immediate medical attention if any of these rare but very serious side effects occur: severe dizziness, fainting, slow heartbeat, seizures.
Subscribe to the Men's Health newsletter for the latest on disease prevention, fitness, sex, nutrition, and more from WebMD.
Some conditions may become worse when the drug is stopped abruptly.
Thioridazine is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions) in people who have already been treated with at least 2 other medications and have not been helped or who have experienced severe side.
For all patients:
If you experience any of the following symptoms, call your doctor immediay: fast, irregular, or pounding heartbeat; dizziness; lightheadedness; or fainting.
Generic alternatives may be available. ¶ This branded product is no longer on the market.
Store it at room temperature and away from excess heat and moisture (not in the bathroom). Keep this medication in the container it came in, tightly closed, and out of reach of children.
Do not try to test for pregnancy at home. Thioridazine may interfere with the results of home pregnancy tests.
Easy to read patient leaflet for thioridazine. Includes indications, proper use, special instructions, precautions, and possible side effects.
Subscribe to receive notifications whenever new articles are published.
Thioridazine may increase your risk of severe and possibly fatal irregular heartbeat. Thioridazine should only be used in patients who have not shown improvement with or are unable to take other medicines.
The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices.
This is only a brief summary of general information about thioridazine.
Thioridazine (Mellaril or Melleril) is a piperidine typical antipsychotic drug belonging to the phenothiazine drug group and was previously widely used in the treatment of schizophrenia and psychosis. The branded product was withdrawn worldwide in 2005 because it caused severe cardiac arrhythmias.
The manufacturer Novartis /Sandoz/Wander of the brands of thioridazine, Mellaril in the USA and Canada and Melleril in Europe, discontinued the drug worldwide in June 2005.
As with all antipsychotics thioridazine has been linked to cases of tardive dyskinesia (an often permanent neurological disorder characterised by slow, repetitive, purposeless and involuntary movements, most often of the facial muscles, that is usually brought on by years of continued treatment with antipsychotics, especially the first-generation (or typical ) antipsychotics such as thioridazine) and neuroleptic malignant syndrome (a potentially fatal complication of antipsychotic treatment).