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Zolpidem hypnotic

Hypnotic drug risks of mortality, infection, depression, and cancer

9.17.2017 | Jessica MacAdam

This is a review of hypnotic drug risks and benefits, reassessing and a significantly-increased adjusted risk of cancer mortality for zolpidem.

Of studies analyzing follow-ups of 8 years or less, 22 of 26 studies reported a significant association, but of studies with longer follow-ups, only 10 of 14 studies observed significant mortality risks. Mixing weakens the risk-ratio contrasts observed. In long follow-ups, one is also studying the selected survivors of the more marked short-term risks that have been recently described 14, 15. This may suggest that during long prospective follow-ups, many patients initially taking hypnotics will discontinue hypnotic usage, whereas many controls not using hypnotics at prospective baseline may have begun using hypnotics during a long follow-up, so that the longer the follow-up, the more mixing of hypnotic-consuming and control groups becomes likely.

The Non-Benzodiazepine Hypnotic Zolpidem Impairs Sleep

4.12.2017 | Jessica MacAdam

Citation: Seibt J; Aton SJ; Jha SK; Coleman T; Dumoulin MC; Frank MG. The non-benzodiazepine hypnotic zolpidem impairs sleep-dependent cortical plasticity.

Indices of 1 indicate a high degree of selectivity, and indices of 0 indicate lack of selectivity. 29. Ratios of unit firing rates were calculated (response at 90°/preferred, or 45°/preferred) and subtracted from 1. Orientation Selectivity Index (OSI): The selectivity for a given orientated stimulus was assessed for both eyes using a previously used metric (OSI). 29 Mean firing rates were computed at each neuron's preferred stimulus orientation and the orthogonal (90° from preferred; OSI90) or the 45° (45° from preferred; OSI45°) orientation.

Single-unit data were discriminated offline (Offline Sorter; Plexon, Inc.; Dallas, TX) and mean response properties for all stimuli were calculated for each sorted neuron by a custom computer program.

Mechanism of action of the hypnotic zolpidem in vivo - NCBI

6.14.2017 | Logan Miers

Zolpidem is a widely used hypnotic agent acting at the GABAA receptor benzodiazepine site. On recombinant receptors, zolpidem displays a high affinity to.

(2) The second approach was based on the recognition that GABA A receptors are divided into subtypes which differ in their subunit composition and regional distribution in the brain (for review, see Möhler, 2000 ; Möhler et al., 2000 ). In the search for ligands with a selective pharmacological profile two lines of research have been followed. The triazolopyridazine {"type":"entrez-nucleotide","attrs": } CL218872 was the first ligand which displayed a differential affinity for the benzodiazepine site, since it displaced [3H]-diazepam with higher affinity from cerebellar than from hippocampal or cortical membranes ( Lippa et al., 1979 ).

The Behavioral Profde of Zolpidem, a Novel Hypnotic Drug of

11.19.2017 | Logan Miers
Zolpidem hypnotic

The behavioralprofile ofzolpidem, a novel hypnotic drug ofimidazopyridine structure. PHYSIOL BEHAV 41(3) 235-240, 1987.--The imidazopyridine zolpidem has.

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The behavioral profile of zolpidem is consistent with the suggestion that this compound may have selective sedative action produced by activity at a sub-type of benzodiazepine receptor. The imidazopyridine zolpidem has previously been shown to displace benzodiazepines from their receptors, with a preferential activity at BZ 1 sites, and to exert hypnotic activity in man. These differences appeared to be qualitative rather than quantitative with the stimulus properties of zolpidem being related to the drug's sedative action. In conditions where tolerance developed rapidly to the depressant activity of benzodiazepines little tolerance was seen with zolpidem. However, unlike benzodiazepines, zolpidem exerts sedative actions at relatively low doses. In drug discrimination experiments differences between the internal stimuli produced by chlordiazepoxide and zolpidem were identified. Zolpidem's pharmacological profile includes anticonvulsant, antipunishment and behavioral depressant actions.

Zolpidem, a novel nonbenzodiazepine hypnotic. I

5.13.2017 | Jessica MacAdam
Zolpidem hypnotic

J Pharmacol Exp Ther. 1986 May;237(2):649-58. Zolpidem, a novel nonbenzodiazepine hypnotic. I. Neuropharmacological and behavioral effects. Depoortere H.