Schiff adds. "These findings give us a very important lead to follow, and we will now rigorously test their implications in other patients.". "We are focused on finding ways to identify patients who have a functional reserve of cognitive capacities that can be rescued and how to achieve this result," Dr.
After a near drowning deprived his brain of oxygen, Melendez remained in a fitful, minimally conscious state until his mother, in 2002, decided to give him the sleep aid drug Ambien to quiet his moaning and writhing. He has been using the drug ever since to maintain awareness, but no one could understand why Ambien led to such an awakening. The next thing she knew, her son was quietly looking at her and trying to talk. George Melendez has been called a medical miracle.
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Schiff. Although it is not precisely known how many Americans are diagnosed as severely brain injured with disorders of consciousness, by one estimate there are nearly 300,000 patients trapped in a minimally conscious state who may retain some awareness, according to Dr.
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"These findings may help predict other patients who might similarly harbor reserve capacity, whether they are able to respond to Ambien or other approaches." Dr. "We found a surprisingly consistent picture of electrical activity in all three patients before they receive the drug. Most interesting is that their specific pattern of activity suggests a particular process occurring in the brain cells of the cerebral cortex and also supports the role of a crucial brain circuit," says the study's senior investigator, Dr. Katz Professor of Neurology and Neuroscience and professor of public health at Weill Cornell. Schiff is also on the faculty of the Feil Family Brain and Mind Research Institute at Weill Cornell and is a neurologist at NewYork-Presbyterian Hospital/Weill Cornell Medical Center. Nicholas Schiff, the Jerold B.
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Story Source:. "Now that we have uncovered important insight into fundamental mechanisms underlying the dramatic and rare response of some severely brain-injured patients to Ambien, we hope to systematically explore ways to achieve such kick-starts in other patients -- that is our goal," Dr. Schiff says.
The resting EEG pattern the researchers saw in the patients indicates they have a "recruitable reserve" of function in these critical brain areas that Ambien can harness to turn the brain on, even if only temporarily. Schiff says. "The idea is that hopefully we can screen other patients with EEG to find out if they also have such a reserve," Dr.
"What we think is happening in these patients is that the initial excitation produced by Ambien turns on a specific circuit. The drug creates the opportunity for the brain to effectively catch a ride on this initial wave of excitation, and turn itself back on," Dr. Instead of going on to produce sedation and sleep, as it does in healthy people who use the drug, zolpidem further activates the brain after it's affected the idling cells, allowing the patients to become more awake than at baseline. Schiff says. In this setting of an idling brain, the investigators propose that Ambien works like any anesthesia drug, in that it briefly triggers a fast wave of excitation in brain cells before producing sleep -- a phenomenon known as paradoxical excitation.
Different Ways to Kick-Start the Brain.
All three patients -- two men and a woman -- become aware when Ambien was used, a rare response that has been documented in fewer than 15 brain-injured patients. Melendez was in a car accident that led to his nearly drowning. The three patients in the study suffered brain damage in different ways. One fell and the other had a brain aneurysm that led to multiple strokes.
Although each patient's brain was damaged in different ways, all showed the same unique features of low frequency waves in their EEG readings. These low frequency oscillations are most prominent over the frontal cortex, a region strongly dependent for its activity on other brain structures, particularly the central thalamus and the striatum, which together support short-term memory, reward, motivation, attention, alertness and sleep, among other functions.
Schiff says. This proposed "mesocircuit" links the cortical regions of the brain to the central thalamus and striatum. Neurons in the striatum "will only fire if there is a lot of electrical input coming to them quickly," he says. Neurons in the central thalamus are highly connected to other parts of the brain, "so damage in one part of the brain or another will affect the thalamus, which is key to consciousness," Dr.
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Riding a Wave of Excitation.
For example, two drugs (amantadine and L-Dopa) that provide extra dopamine, a brain chemical that fuels the part of the brain damaged in the study's patients, have been shown to have similar effects on restoring function in patients with severe brain injuries, as has electrical brain stimulation of the central thalamus. And while some of these patients may not respond to Ambien -- as the drug works at a very specific brain receptor and individuals can vary considerably in having enough of it in the key components of the proposed circuit -- other drugs may target the same structures and potentially produce similar effects, he says.
The research team, which included scientists from Memorial Sloan-Kettering Cancer Center, Boston University School of Medicine, and the University Hospital of Liège in Belgium, used EEG to measure electrical activity in the patients' brains before and after they were given the drug.
Now, a team of scientists led by Weill Cornell Medical College has discovered a signature of brain activity in Melendez and two other similarly "awakened" patients they say explain why he and others regain some consciousness after using Ambien or other drugs or treatments. 19 in the journal eLife, was identified by analyzing the common electroencephalography (EEG) test, which tracks brain waves. The pattern of activity, reported Nov.
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Schiff says. The pattern of brain activity seen in the EEG on Ambien was also the same in all the patients in the study. The first patient in the study can reliably move from minimally conscious to "the mid-range of what is called a confusional state -- a more alert status, but not full consciousness," Dr. His tremors and spasticity are significantly reduced on Ambien and he can use objects, such as a spoon, and is alert and can communicate. But the circuit turns off again when the effects of the drug diminish. "Use of Ambien offers a step in the right direction, but certainly not a cure.". Using the drug regularly at mealtimes, Melendez can speak fluently, and read and write simple phrases.
"We believe the switch that Ambien turns on is at the level of the joint connections between these three brain structures," Dr. Schiff says.Ambien daily