Learn about Sinequan (Doxepin) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related.
Specifically, it is an isomeric mixture of: 1-Propanamine, 3-dibenzoxepin-11(6H)ylidene-N,N-dimethyl-, hydrochloride. SINEQUAN (doxepin HCl) is a dibenzoxepin derivative and is the first of a family of tricyclic psychotherapeutic agents.
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Owing to lack of clinical experience in the pediatric population, SINEQUAN is not recommended for use in children under 12 years of age.
Doxepin HCL Capsule. This medication is used to treat mental/mood problems such as depression and anxiety. This medication belongs to a class of medications called tricyclic antidepressants.
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Take this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time(s) each day. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.
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To relieve dry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.
Many drugs besides doxepin may affect the heart rhythm (QT prolongation in the EKG ), including amiodarone, cisapride, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (such as erythromycin ), among others.
Low-dose doxepin may relieve sleep maintenance insomnia and is not designated as a controlled substance.
Next-day alertness was assessed using the Visual Analogue Scale (VAS) for sleepiness, and the Digit-Symbol Substitution Test (DSST) and the Symbol-Copying Task (SCT) for psychomotor function. Improved sleep onset was seen only with the 6 mg dose. 4 In this study, patients taking doxepin at all doses achieved improvement in objective (PSG-defined) and subjective (patient-reported) measures of sleep duration and sleep maintenance. In addition, PSG indicators of early-morning awakenings (terminal insomnia) were reduced, as shown by an increase in SE during the final third of the night and the 7th and 8th hours of sleep (1, 3, and 6 mg doses) and a reduction in wake time after sleep (WTAS) during the final third of the night (6 mg only).
Easy to read patient leaflet for doxepin. Includes indications, proper use, special instructions, precautions, and possible side effects.
It may also be used for other conditions as determined by your doctor. Treating insomnia (trouble sleeping) in patients who have trouble staying asleep.
Other brands: Silenor, Sinequan.
It is thought that doxepin works by blocking the effects of histamine in the brain. This helps you to stay asleep after you fall asleep. Doxepin is a sleep medicine. Exactly how it works is not known.
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Pregnancy Category N Not classified.
Approval History Calendar Drug history at FDA.
Check the label on the medicine for exact dosing instructions.
A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as doxepin.
Do not mix it with carbonated beverages (soft drinks). Ask your pharmacist to show you how to use the dropper. Dilute the concentrate in 4 ounces (120 mL) of water; whole or skim milk; or orange, grapefruit, tomato, prune, or pineapple juice just before taking it. Doxepin concentrate (oral liquid) comes with a specially marked dropper for measuring the dose.
You should know that your mental health may change in unexpected ways when you take doxepin or other antidepressants even if you are an adult over age 24.