Disulfiram should never be administered to a patient when he is in a state of alcohol intoxication, or without his full knowledge. Each tablet for oral administration contains 250 mg or 500 mg disulfiram, USP. The average maintenance dose is 250 mg daily (range, 125 to 500 mg), it.
Patients with a history of rubber contact dermatitis should be evaluated for hypersensitivity to thiuram derivatives before receiving disulfiram (see CONTRAINDICATIONS ).
This test dose of alcoholic beverage may be repeated once only, so that the total dose does not exceed 30 mL (1 oz) of whiskey. Once a reaction develops, no more alcohol should be consumed. After the first one to two weeks' therapy with 500 mg daily, a drink of 15 mL (½ oz) of 100 proof whiskey, or equivalent, is taken slowly.
WARNING: Disulfiram should never be administered to a patient when he is in a state of alcohol intoxication, or without his full knowledge. The physician should.
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Disulfiram Tablets USP:. Potassium levels should be monitored, particularly in patients on digitalis, since hypokalemia has been reported. Antihistamines have also been used intravenously. Other recommendations include: oxygen, carbogen (95% oxygen and 5% carbon dioxide), vitamin C intravenously in massive doses (1 g) and ephedrine sulfate. In severe reactions, whether caused by an excessive test dose or by the patient’s unsupervised ingestion of alcohol, supportive measures to restore blood pressure and treat shock should be instituted.
INCREASED PHENYTOIN LEVELS SHOULD BE TREATED WITH APPROPRIATE DOSAGE ADJUSTMENT.
Find patient medical information for Antabuse Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Before using this medication, l your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: amitriptyline, " blood thinners " (e.g., warfarin ), certain medications for seizures (e.g., hydantoins such as phenytoin/fosphenytoin), isoniazid, theophylline.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at.
If this medication causes drowsiness, take it at bedtime. Take this medication by mouth with or without food, usually once daily in the morning or as directed by your doctor.
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I have no financial interest in Antabuse or any maker of Antabuse. I simply believe, based on the medical evidence, that Antabuse increases the chances of.
Any drug can have any possible side effect. But that doesn't mean we should stop using Tylenol. You can never say never in medicine. And the benefits of Antabuse outweigh the risks of drinking. Every year people die from taking Tylenol (acetaminophen). The benefits far outweigh the risks.
It works because if you know you can't drink, then you won't think about drinking as much. Antabuse works by making you sick to your stomach if you have a drink.
It gives you plenty of time to reconsider, restart your Antabuse, and ask for help.
Antabuse (disulfiram) blocks an enzyme that is involved in metabolizing alcohol intake. Disulfiram produces very unpleasant side effects when combined with alcohol in the body. This medicine can help keep you from drinking because of the unpleasant side effects that will occur if.
Pregnancy Category C Risk cannot be ruled out.
you have consumed any foods or products that contain alcohol (mouthwash, cough medicine, cooking wine or vinegar, certain desserts, and others).
confusion, unusual thoughts or behavior; or.
l your doctor if you are pregnant or plan to become pregnant while using this medicine. FDA pregnancy category C. It is not known whether Antabuse will harm an unborn baby.
See also: Pregnancy and breastfeeding warnings (in more detail).
liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Approval History 10+ years FDA approved 1951.
When Antabuse is used as part of a treatment program for alcohol addiction or detoxification, your doctor may recommend that this medicine be given to you by a family member or other caregiver.