REMERON (mirtazapine) Tablets are an orally administered drug. Mirtazapine has a tetracyclic chemical structure and belongs to the.
Bottles of 30 NDC.
Call your doctor at once if you have a serious side effect such.
The clinician should, nevertheless, be aware of the possibility of emergent symptoms of serotonin syndrome with such use (see WARNINGS ). The risk of administering methylene blue by non-intravenous routes (such as oral tablets or by local injection) or in intravenous doses much lower than 1 mg/kg with REMERON is unclear.
A major depressive episode ( DSM-IV ) implies a prominent and relatively persistent (nearly every day for at least 2 weeks) depressed or dysphoric mood that usually interferes with daily functioning, and includes at least 5 of the following 9 symptoms: depressed mood, loss of interest in usual activities, significant change in weight and/or appetite, insomnia or hypersomnia, psychomotor agitation or retardation, increased fatigue, feelings of guilt or worthlessness, slowed thinking or impaired concentration, a suicide attempt, or suicidal ideation.
Musculoskeletal System: frequent : myasthenia, arthralgia ; infrequent : arthritis, tenosynovitis; rare : pathologic fracture, osteoporosis fracture, bone pain, myositis, tendon rupture, arthrosis, bursitis.
Nervous System: frequent : hypesthesia, apathy, depression, hypokinesia, vertigo, twitching, agitation, anxiety, amnesia, hyperkinesia, paresthesia ; infrequent : ataxia, delirium, delusions, depersonalization, dyskinesia, extrapyramidal syndrome, libido increased, coordination abnormal, dysarthria, hallucinations, manic reaction, neurosis, dystonia, hostility, reflexes increased, emotional lability, euphoria, paranoid reaction; rare : aphasia, nystagmus, akathisia (psychomotor restlessness), stupor, dementia, diplopia, drug dependence, paralysis, grand mal convulsion, hypotonia, myoclonus, psychotic depression, withdrawal syndrome, serotonin syndrome.
Patients should be monitored for these and other symptoms when discontinuing treatment or during dosage reduction.
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It may take between 1-4 weeks to notice improvement in your symptoms. Use this medication regularly in order to get the most benefit from it. Therefore, do not increase your dose or take it more often than prescribed. Remember to use it at the same time each day.
However, since untreated mental/ mood disorders (such as depression ) can be a serious condition, do not stop taking this medication unless your doctor directs you to do so.
Mirtazapine, originally branded Remeron, is an atypical antidepressant with noradrenergic and specific serotonergic activity. It blocks the α2 adrenergic auto.
Concurrent use with inhibitors or inducers of the cytochrome (CYP) P450 isoenzymes CYP1A2, CYP2D6, and/or CYP3A4 can result in altered concentrations of mirtazapine, as these are the main enzymes responsible for its metabolism. As examples, fluoxetine and paroxetine, inhibitors of these enzymes, are known to modestly increase mirtazapine levels, while carbamazepine, an inducer, considerably decreases them.
Mirtazapine and other antidepressants may cause a discontinuation syndrome upon cessation.
Remeron (mirtazapine) is an antidepressant. Remeron is used to treat major depressive disorder. Remeron may also be used for purposes not listed in this medication guide.
Pregnancy Category C Risk cannot be ruled out.
Availability Rx Prescription only.
You should not take Remeron if you are allergic to mirtazapine, or if you are also taking tryptophan (sometimes called L-tryptophan).
It may take up to several weeks before your symptoms improve. Keep using the medication as directed and l your doctor if your symptoms do not improve after 4 weeks of treatment.
See also: Dosage Information (in more detail).
Your family or other caregivers should also be alert to changes in your mood or symptoms.
Remeron might be the most effective antidepressant. Of the top 12 most prescribed antidepressants, an article in Lancet ranked Remeron #1:.
The potent antihistamine effect of Remeron promotes sleep and results in sedation as a major side effect. As can be seen from the above table, Remeron antagonizes (blocks) with high affinity histamine receptors (specifically, the H1 subtype), as well as the serotonin receptor 5HT2A.
↩. 2009; : 746-58. Lancet (London, England). Cipriani A, Furukawa TA, Salanti G, et al. Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis.
This sedation can benefit individuals with anxiety.