Learn about Darvon (Propoxyphene) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related.
Coadministration with agents that induce CYP3A4 activity may reduce the efficacy of propoxyphene. Strong CYP3A4 inducers such as rifampin may lead to enhanced metabolite (norpropoxyphene) levels. The metabolism of propoxyphene may be altered by strong CYP3A4 inhibitors (such as ritonavir, ketoconazole, itraconazole, troleandomycin, clarithromycin, nelfinavir, nefazadone, amiodarone, amprenavir, aprepitant, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, and verapamil) leading to enhanced propoxyphene plasma levels.
Neonates whose mothers have taken opiates chronically may exhibit respiratory depression or withdrawal symptoms.
Propoxyphene is in a group of drugs called narcotic pain relievers. Propoxyphene is used to relieve mild to moderate pain. Dangerous side effects or death can occur when alcohol is combined with a narcotic pain medicine.
nausea, vomiting, stomach pain, constipation; headache, muscle pain; blurred vision; or mild skin rash.
Keep track of how many pills have been used from each new bottle of this medicine. Propoxyphene is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.
HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva), etravirine (Inence), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), saquinavir (Invirase), or ritonavir (Norvir);
Follow the directions on your prescription label.
A new clinical trial has linked propoxyphene use with a higher risk of developing serious and sometimes fatal heart rhythm abnormalities due to.
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Find a comprehensive guide to possible side effects including common and rare side effects when taking Darvon (Propoxyphene) for.
Gastrointestinal disorder: gastrointestinal bleed, acute pancreatitis.
Nervous system disorder: ataxia, coma, dizziness, somnolence, syncope.
Propoxyphene therapy has been associated with abnormal liver function tests and, more rarely, with instances of reversible jaundice (including cholestatic jaundice). Liver dysfunction has been reported in association with Darvon.
Pill Identifier Tool Quick, Easy, Pill Identification.
In chronic pain patients, and in opioid-tolerant cancer patients, the administration of Darvon (propoxyphene) should be guided by the degree of tolerance manifested and the doses needed to adequay relieve pain.
Call your doctor at once if you have any of these serious side effects:
l your doctor if you have serious side effects of Darvon (propoxyphene) including:
You may report side effects to FDA at 1-800-FDA-1088.
Propoxyphene is an opioid pain reliever used to treat mild to moderate pain. It is sold under various names as a single-ingredient product (e.g., Darvon) and as part of a combination product with acetaminophen (e.g., Darvocet).
* QTcF is the QT interval corrected for heart rate using the Fridericia formula (cubic root – QTcF = QT/RR1/3). References MedWatch Online.
Dispose of unused propoxyphene in your household trash by following the recommendations outlined in the Federal Drug Disposal Guidelines:
Additional Information for Patients.
FDA recommends that healthcare professionals: Data Summary.
Mail to: MedWatch 5600 Fishers Lane.
Regular Mail: Use postage-paid FDA Form 3500.
The U.S. FDA has requested that companies voluntarily withdraw propoxyphene from the United States market.