Learn about the potential side effects of Retrovir (zidovudine). Includes common and rare side effects information for consumers and healthcare professionals.
Zidovudine therapy has been associated with lower levels of vitamins B2 and C, folate, and zinc despite adequate dietary intake. Other side effects have included malaise (up to 53.2%), asthenia (up to 9%), fatigue (5% or greater), chills (5% or greater), and fever. Back pain, chest pain, influenza-like syndrome, generalized pain, syncope, and taste perversion have been reported during postmarketing experience.
46. Gertner E, Thurn JR, Williams DN, et al "Zidovudine-associated myopathy." Am J Med 86 (1989): 814-8.
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Levine JD, Allan JD, Tessitore JH, et al "Recombinant human granulocyte-macrophage colony-stimulating factor ameliorates zidovudine-induced neutropenia in patients with acquired immunodeficiency syndrome." Blood 12 (1991): 3148-54.
RETROVIR is the brand name for zidovudine (formerly called azidothymidine [AZT]), a pyrimidine nucleoside analogue active against HIV-1.
Concomitant use of zidovudine with stavudine should be avoided since an antagonistic relationship has been demonstrated in vitro.
The frequency and severity of adverse reactions associated with the use of RETROVIR are greater in patients with more advanced infection at the time of initiation of therapy.
In patients who develop significant anemia, dose interruption does not necessarily eliminate the need for transfusion. Significant anemia ( hemoglobin less than 7.5 g per dL or reduction greater than 25% of baseline) and/or significant neutropenia ( granulocyte count less than 750 cells per mm³ or reduction greater than 50% from baseline) may require a dose interruption until evidence of marrow recovery is observed.
Zidovudine belongs to a class of drugs known as nucleoside reverse transcriptase inhibitors-NRTIs. Zidovudine is used in pregnant women to prevent passing the HIV virus to the unborn baby. This medication is also used in newborns born to mothers infected with HIV to prevent infection in the newborns.
While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval. To help your doctor and pharmacist give you the best care, be sure to l your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product.
This medication works best when the amount of drug in your body is kept at a constant level. Therefore, take this drug at evenly spaced intervals.
Retrovir is a nucleoside reverse transcriptase inhibitor HIV Medication. Retrovir was the first drug approved by the FDA in 1987.
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Retrovir must be used in combination with other HIV drugs.
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Before taking this medication, l your doctor if you have kidney disease or liver disease.
Retrovir is an anti-HIV medication. It is in a category of HIV medications called nucleoside reverse transcriptase inhibitors (NRTIs). Retrovir prevents HIV from.
Retrovir prevents HIV from altering the genetic material of healthy T-cells. Generic versions of zidovudine for distribution in the United States were approved in September 2005: zidovudine tablets (made by Ranbaxy Laboratories of Gurgaon, India; Aurobindo Pharma of Hyderabad, India; and Roxane Laboratories of Columbus, Ohio) and zidovudine oral solution (made by Aurobindo Pharma). There are actually five ways that Retrovir can be prescribed:. Retrovir, manufactured by GlaxoSmithKline, was the first drug approved for the treatment of HIV, in 1987.