WARNING. CARDIOVASCULAR RISK ASSOCIATED WITH RAPID INFUSION. The rate of intravenous Dilantin administration should not.
As non-emergency therapy, Dilantin should be administered more slowly as either a loading dose or by intermittent infusion. Because of the risks of cardiac and local toxicity associated with intravenous Dilantin, oral phenytoin should be used whenever possible.
Ordinarily, Dilantin should not be given intramuscularly because of the risk of necrosis, abscess formation, and erratic absorption. An intramuscular dose 50% greater than the oral dose is necessary to maintain these levels. When returned to oral administration, the dose should be reduced by 50% of the original oral dose for one week to prevent excessive plasma levels due to sustained release from intramuscular tissue sites.
Dilantin (phenytoin) is an anti-epileptic drug, also called an anticonvulsant. If you become pregnant while taking Dilantin, DO NOT STOP TAKING the medicine without your doctor's advice. Seizure control is very important during pregnancy and the benefits of preventing seizures may.
Some mixtures of medications can lead to serious and even fatal consequences.
Approval History Calendar Drug history at FDA.
This type of reaction can start several weeks after you begin using this medicine. In rare cases, phenytoin may cause a severe drug reaction that can affect many parts of the body.
dizziness, drowsiness, confusion, nervousness;
Dilantin is used to control seizures. Phenytoin does not treat all types of seizures, and your doctor will determine if it is the right medicine for you.
Patients of Asian ancestry may have a higher risk of developing a rare but serious skin reaction to phenytoin.
Find patient medical information for Dilantin Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
A small number of people who take anticonvulsants for any condition (such as seizure, bipolar disorder, pain) may experience depression, suicidal thoughts/attempts, or other mental/mood problems. l your doctor right away if you or your family/caregiver notice any unusual/sudden changes in your mood, thoughts, or behavior including signs of depression, suicidal thoughts/attempts, thoughts about harming yourself.
However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching /swelling (especially of the face/ tongue /throat), severe dizziness, trouble breathing.
Phenytoin, sold under the brand name Dilantin among others, is an anti-seizure medication. It is useful for the prevention of tonic-clonic seizures, partial seizures.
Some clinical trials have explored whether phenytoin can be used as neuroprotector in multiple sclerosis.
Abrupt discontinuation of phenytoin can precipitate status epilepticus.
Severe low blood pressure and abnormal heart rhythms can be seen with rapid infusion of IV phenytoin. IV infusion should not exceed 50 mg/min in adults or 1–3 mg/kg/min (or 50 mg/min, whichever is slower) in children. Due to these risks, oral phenytoin should be used if possible. Heart monitoring should occur during and after IV infusion.
It was approved by the United States Food and Drug Administration in 1953 for use in seizures.
Because it takes time for the bound drug to dissociate from the inactive channel, there is a time dependent block of the channel.
Get the DILANTIN Savings Card and learn about DILANTIN (extended phenytoin sodium capsules, USP). See risks and benefits.
If you take DILANTIN during pregnancy, your baby is at risk for serious birth defects and bleeding problems right after birth. l your doctor if you are breastfeeding or plan to breastfeed. All women of child-bearing age should talk to their healthcare provider about using other possible treatments instead of DILANTIN. DILANTIN can pass into breast milk. Your healthcare provider may give you and your baby medicine to prevent this.
Only your doctor can recommend changing your medication. When a change in the dosage form or brand is prescribed, careful monitoring of phenytoin serum levels should be carried out by your doctor.