ZESTORETIC (Lisinopril and Hydrochlorothiazide) combines an angiotensin converting enzyme inhibitor, lisinopril, and a diuretic, hydrochlorothiazide. Lisinopril, a synthetic peptide derivative, is an oral long-acting angiotensin converting enzyme inhibitor.
Clinical adverse experiences occurring in 0.3% to 1.0% of patients in controlled trials and rarer, serious, possibly drug-related events reported in marketing experience are listed below:
Hydrochlorothiazide is 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C 7 H 8 QN and its structural formula is:.
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In clinical trials, 0.4% of patients discontinued therapy due to anemia.
Zestoretic (Lisinopril and Hydrochlorothiazide) combines an angiotensin converting enzyme inhibitor, lisinopril, and a diuretic, hydrochlorothiazide. The Zestoretic 10-12.5 combination worked equally well in black and white patients. The Zestoretic 20-12.5 and Zestoretic 20-25.
Hypotension and Related Effects: Excessive hypotension was rarely seen in uncomplicated hypertensive patients but is a possible consequence of lisinopril use in salt/volume-depleted persons such as those treated vigorously with diuretics or patients on dialysis (See PRECAUTIONS, Drug Interactions and ADVERSE REACTIONS ).
This terminal phase probably represents saturable binding to ACE and is not proportional to dose.
Zestoretic is indicated in the management of mild to moderate hypertension in patients who have been stabilised on the individual components.
As with all other medication taken once daily, Zestoretic should be taken at approximay the same time each day. The usual dosage is one tablet, administered once daily.
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In clinical studies the efficacy and tolerability of lisinopril and hydrochlorothiazide, administered concomitantly, were similar in both elderly and younger hypertensive patients.
Exacerbation or activation of systemic lupus erythematosus has been reported with the use of thiazides. In patients receiving thiazides, hypersensitivity reactions may occur with or without a history of allergy or bronchial asthma.
round, yellow, imprinted with MSD 140, PRINZIDE.
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What are the possible side effects of hydrochlorothiazide and lisinopril (Zestoretic)?
What other drugs will affect hydrochlorothiazide and lisinopril (Zestoretic)?
l your doctor if you have a prolonged illness that causes diarrhea or vomiting. Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low salt diet, or taking diuretics (water pills).
Drug information contained herein may be time sensitive.
Pictures of Zestoretic (Lisinopril and Hydrochlorothiazide), drug imprint information, side effects for the patient.
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Drinking alcohol can increase certain side effects of hydrochlorothiazide and lisinopril.
The combination of hydrochlorothiazide and lisinopril is used to treat hypertension (high blood pressure).
Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.
Lisinopril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme.