Other drugs may interact with acetaminophen and hydrocodone, including prescription and over-the-counter medicines, vitamins, and herbal products. l each of your health care providers about all medicines you use now and any medicine you start or stop using.
Acetaminophen is a less potent pain reliever that increases the effects of hydrocodone.
We comply with the HONcode standard for trustworthy health information - verify here.
Common side effects include: drowsiness; upset stomach, constipation; headache; blurred vision; or dry mouth.
An overdose of acetaminophen and hydrocodone can be fatal. Seek emergency medical attention or call the Poison Help line at.
a colostomy or ileostomy; kidney disease;
This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. This is not a complete list of side effects and others may occur.
Subscribe to receive notifications whenever new articles are published.
Avoid driving or operating machinery until you know how acetaminophen and hydrocodone will affect you. This medication may impair your thinking or reactions. Dizziness or severe drowsiness can cause falls or other accidents.
Availability Rx Prescription only.
Back Pain tramadol, Cymbalta, naproxen, aspirin, ibuprofen, duloxetine, diclofenac, Norco, More.
Overdose symptoms may also include extreme drowsiness, pinpoint pupils, cold and clammy skin, muscle weakness, fainting, weak pulse, slow heart rate, coma, blue lips, shallow breathing, or no breathing.
bowel obstruction, severe constipation;
l your doctor if the medicine seems to stop working as well in relieving your pain. An overdose can damage your liver or cause death. Never take this medicine in larger amounts, or for longer than prescribed. Follow all directions on your prescription label.
Keep track of the amount of medicine used from each new bottle. Hydrocodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.
a light-headed feeling, like you might pass out;
asthma, COPD, sleep apnea, or other breathing disorders.
nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Narcotic pain medicine may be habit-forming, even at regular doses. Never use this medicine in larger amounts, or for longer than prescribed. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Hydrocodone can slow or stop your breathing. Keep the medication in a place where others cannot get to it.
low blood pressure, or if you are dehydrated;
If you do not have a dose-measuring device, ask your pharmacist for one. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup.
A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. Do not use this medicine if you have taken an MAO inhibitor in the past 14 days.
Ask your doctor before taking acetaminophen and hydrocodone with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures. Taking this medicine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects.
Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Check the label to see if a medicine contains acetaminophen or APAP. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose.
Ask the pharmacist if you have any questions about the medicine you receive at the pharmacy. Always check your bottle to make sure you have received the correct pills (same brand and type) of medicine prescribed by your doctor.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Data sources include Micromedex (updated June 2nd, 2017), Cerner Multum (updated June 5th, 2017), Wolters Kluwer (updated June 6th, 2017) and others. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. To view content sources and attributions, please refer to our editorial policy. provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products.
If you use narcotic medicine while you are pregnant, your baby could become dependent on the drug. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. This can cause life-threatening withdrawal symptoms in the baby after it is born. l your doctor if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby.
It may increase your risk of liver damage while taking acetaminophen. Avoid drinking alcohol.
MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.
Hydrocodone may be habit-forming, even at regular doses. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Selling or giving away acetaminophen and hydrocodone is against the law. MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.
Skip the missed dose if it is almost time for your next scheduled dose. Since acetaminophen and hydrocodone is taken as needed, you may not be on a dosing schedule. Do not use extra medicine to make up the missed dose. If you are taking the medication regularly, take the missed dose as soon as you remember.
confusion, unusual thoughts or behavior; seizure (convulsions);
Call your doctor at once if you have:
In rare cases, acetaminophen may cause a severe skin reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.
shallow breathing, slow heartbeat;
CSA Schedule 2 High potential for abuse.
Pain tramadol, acetaminophen, Tylenol, naproxen, oxycodone, aspirin, ibuprofen, amitriptyline, More.
Acetaminophen and hydrocodone is a combination medicine used to relieve moderate to severe pain.
Store at room temperature away from moisture and heat.
diarrhea, inflammatory bowel disease;
Acetaminophen and hydrocodone may also be used for purposes not listed in this medication guide.
Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.
See also: Side effects (in more detail).
You should not breast-feed while using this medicine. Acetaminophen and hydrocodone can pass into breast milk and may harm a nursing baby.
Hydrocodone is an opioid pain medication. An opioid is sometimes called a narcotic.
a history of alcoholism or drug addiction;
Generic Name: acetaminophen and hydrocodone (a SEET a MIN oh fen and hye droe KOE done) Brand Name: Hycet, Lorcet, Lortab 10/325, Lortab 5/325, Lortab 7.5/325, Lortab Elixir, Norco, Verdrocet, Vicodin, Xodol, Zolvit.
Do not stop using this medicine suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using acetaminophen and hydrocodone.
Pregnancy Category C Risk cannot be ruled out.
To make sure this medicine is safe for you, l your doctor if you have:
easy bruising or bleeding; or.
This medicine is more likely to cause breathing problems in older adults and people who are severely ill, malnourished, or otherwise debilitated.
l any doctor who treats you that you are using acetaminophen and hydrocodone. This medicine can cause unusual results with certain urine tests.
Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes. The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness.
You should not use this medicine if you are allergic to acetaminophen (Tylenol) or hydrocodone, or if you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications.
liver disease, cirrhosis, or if you drink more than 3 alcoholic beverages per day;
a history of head injury, brain tumor, or stroke; or.
If you need surgery, l the surgeon ahead of time that you are using this medicine. You may need to stop using the medicine for a short time.
An overdose of acetaminophen can damage your liver or cause death. Do not take more of this medicine than is recommended. Call your doctor at once if you have nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of your skin or eyes).
Version: 14.09. Revision Date:, 1:16:42 PM. Cerner Multum, Inc.
Available for Android and iOS devices. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.Lorcet