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Skelaxin



Skelaxin (Metaxalone) Side Effects, Interactions, Warning, Dosage

4.20.2017 | Jennifer Bargeman

SKELAXIN (metaxalone) is available as an 800 mg oval, scored pink tablet. Each tablet contains 800 mg metaxalone and the following inactive ingredients: alginic acid, ammonium calcium alginate, B-Rose Liquid, corn starch, and magnesium stearate. The recommended dose for adults.

The effects of age on the pharmacokinetics of metaxalone were determined following single administration of two 400 mg tablets (800 mg) under fasted and fed conditions. The results were analyzed separay, as well as in combination with the results from three other studies. Using the combined data, the results indicate that the pharmacokinetics of metaxalone are significantly more affected by age under fasted conditions than under fed conditions, with bioavailability under fasted conditions increasing with age.

Digestive: nausea, vomiting, gastrointestinal upset.

Serotonin syndrome has been reported when metaxalone was used at doses higher than the recommended dose (see WARNINGS ).

The pharmacokinetics of metaxalone have been evaluated in healthy adult volunteers after single dose administration of SKELAXIN under fasted and fed conditions at doses ranging from 400 mg to 800 mg.

Other adverse reactions are:

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Known tendency to drug induced, hemolytic, or other anemias.

Hematologic: leukopenia ; hemolytic anemia ; Hepatobiliary: jaundice.

Safety and effectiveness in children 12 years of age and below have not been established.

CNS: drowsiness, dizziness, headache, and nervousness or “irritability”;

The bioavailability of metaxalone under fasted and fed conditions in three groups of healthy volunteers of varying age is shown in Table 2.

Due to the potential for SS, caution is advised when metaxalone is co-administered with drugs that may affect the serotonergic neurotransmitter systems, such as tramadol or SSRIs (see WARNINGS ).

Each tablet contains 800 mg metaxalone and the following inactive ingredients: alginic acid, ammonium calcium alginate, B-Rose Liquid, corn starch, and magnesium stearate.

The mechanism of action of metaxalone in humans has not been established, but may be due to general central nervous system depression.

SKELAXIN is a registered trademark of King Pharmaceuticals Research and Development, Inc.

Thereafter, metaxalone concentrations decline log-linearly with a terminal half-life of 9.0 ± 4.8 hours.

Skelaxin Oral Uses, Side Effects, Interactions, Pictures, Warnings

3.19.2017 | Jennifer Bargeman

Metaxalone is used to treat muscle spasms/pain. If you take this medication after a high-fat meal and experience side effects, it may be best to take this drug on an empty stomach or after a light meal. Do not increase your dose or use this drug more often or for longer than.

In the US.

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If you take this medication after a high- fat meal and experience side effects, it may be best to take this drug on an empty stomach or after a light meal. Take this medication by mouth with or without food as directed by your doctor, usually 3 or 4 times a day.

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Skelaxin Uses, Dosage & Side Effects

5.21.2017 | Logan Miers

Skelaxin (metaxalone) is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) in the brain. Skelaxin is used together with rest and.

Do not take this medicine in larger or smaller amounts or for longer than recommended. Take Skelaxin exactly as it was prescribed for you. Follow all directions on your prescription label.

You should not use Skelaxin if you have anemia (low red blood cells), or severe kidney or liver disease. You may need a dose adjustment or special tests to safely take Skelaxin.

Generic Name: metaxalone (me TAX a lone) Brand Names: Skelaxin.

See also: Side effects (in more detail).

You should not use Skelaxin if you are allergic to metaxalone, or if you have:

Skelaxin may also be used for purposes not listed in this medication guide.

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Dizziness or drowsiness may be more likely in older adults.

Skelaxin is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.

Usual Adult Dose for Muscle Spasm:

Common Skelaxin side effects may include: dizziness, drowsiness;

nausea, vomiting, upset stomach; headache; or.

Skelaxin is only part of a complete treatment program that may also include rest, physical therapy, or other pain relief measures.

Metaxalone, Skelaxin Drug Facts, Side Effects and Dosing

9.25.2017 | Jennifer Bargeman

Skelaxin (metaxalone) is a muscle relaxant and is used in adjunct to physical therapy for treatment of painful muscle spasms.

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Do I need a prescription for metaxalone? Yes.

The most common side effects with metaxalone are:

What brand names are available for metaxalone? Skelaxin.

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Metaxalone

11.27.2017 | Logan Blare
Skelaxin

Metaxalone (marketed by King Pharmaceuticals under the brand name Skelaxin) is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions.

Metaxalone has been used as an internal standard for few analytical methods. Nirogi et al. A literature survey reveals very few methods are reported for the determination of metaxalone to date. Sahu et al. A stability-indicating HPLC method was introduced by P.K. reported a liquid chromatographic method coupled to tandem mass spectrometry for the quantification of metaxalone in human plasma.

Metaxalone exhibits increased bioavailability when taken with food. Thus, based on the information in the labeling, patients receiving metaxalone therapy are directed to take metaxalone with food, and are informed that taking metaxalone with food results in an increase in the oral bioavailability of metaxalone compared to taking metaxalone without food. Specifically, in one study, compared to fasted conditions, the presence of food at the time of drug administration increased C max by 77.5%, AUC 0-t by 23.5%, and AUC 0-∞ by 15.4%.

Skelaxin is available in an 800 mg scored tablet. It is considered to be a moderay strong muscle relaxant, with relatively low incidence of side effects. Possible side effects include nausea, vomiting, drowsiness and CNS side effects, such as dizziness, headache, and irritability. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. Metaxalone (marketed by King Pharmaceuticals under the brand name Skelaxin ) is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions.

As of 2015 the cost for a typical month of medication in the United States is 100 to 200 USD. Because of potential for side effects, this drug is considered high risk in the elderly.

The metabolism of metaxalone involves the liver cytochrome P450 system. Based on the information in the labeling, patients receiving metaxalone therapy and physicians prescribing metaxalone are directed to take precaution when coadministering it with other medications involving the P450 system.