Eldepryl is contra-indicated in patients with known hypersensitivity (including severe dizziness or hypotension) to selegiline or any of the.
Reporting of suspected adverse reactions. When prescribing this medicine, patients should be told: • The medicine is likely to affect your ability to drive • Do not drive until you know how the medicine affects you • It is an offence to drive while under the influence of this medicine • However, you would not be committing offence (called 'statutory defence') if: o The medicine has been prescribed to treat a medical or dental problem and o You have taken it according to the instructions given by the prescriber and in the information provided with the medicine and o It was not affecting your ability to drive safely 4.8 Undesirable effects The following undesirable effects have been reported with selegiline during clinical trials and/or post-marketing use.
Eldepryl Capsules official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more.
Whether or not this mechanism or an alternative one actually accounts for the observed beneficial effects of adjunctive selegiline is unknown. MAO-B inhibition may be useful in this setting because, by blocking the catabolism of dopamine, it would increase the net amount of dopamine available (i.e., it would increase the pool of dopamine).
MAOs are also important in the catabolism of various exogenous amines found in a variety of foods and drugs. MAO in the GI tract and liver (primarily type A), for example, is thought to provide vital protection from exogenous amines (e.g., tyramine) that have the capacity, if absorbed intact, to cause a 'hypertensive crisis,' the so-called 'cheese reaction.' (If large amounts of certain exogenous amines gain access to the systemic circulation - e.g., from fermented cheese, red wine, herring, over-the-counter cough/cold medications, etc.
Eldepryl is indicated for the treatment of Parkinson's disease, or symptomatic parkinsonism. Eldepryl may be used alone in early Parkinson's disease to delay.
Because of the risk of hypertension, co-administration of selegiline and sympathomimetics is contraindicated. Pethidine.
The bioavailability is low; 10% (on average, interindividual variation is large) of unchanged selegiline can reach the systemic circulation.Selegiline is a lipophilic, slightly basic compound, which quickly penetrates into tissues, also into brain. Distribution. The maximal concentrations are reached in 0.5-0.75h after oral administration in fasting state. Selegiline is readily absorbed from the gastro-intestinal tract.
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75-85% of selegiline is bound to plama proteins at therapeutic concentrations.
Find patient medical information for Eldepryl Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Do not share this medication with others.
Some products that may interact with selegiline include: antidepressants (including bupropion, maprotiline, mirtazapine ), other MAO inhibitors ( isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, tranylcypromine ), appetite suppressants (such as diethylpropion ), drugs for attention deficit disorder (such as atomoxetine, methylphenidate ), apraclonidine, buspirone, carbamazepine / oxcarbazepine, cyclobenzaprine, certain herbal products (such as ephedra/ma huang), cold medications/nasal decongestants (such as phenylephrine, phenylpropanolamine, pseudoephedrine ), fentanyl, street drugs (such as LSD, mescaline), stimulants (such as amphetamines, ephedrine ), supplements (such as tryptophan, tyramine), tetrabenazine, certain "triptans" used to treat migraine headaches (such as rizatriptan, sumatriptan, zolmitriptan ).
People with Parkinson's disease may have an increased risk for developing skin cancer ( melanoma ).
Eldepryl capsules are used together with levodopa and carbidopa to treat symptoms of Parkinson's disease. Serious drug interactions can occur when certain medicines are used together with Eldepryl. While taking Eldepryl, do not drink alcohol or eat foods that are high in tyramine.
WADA Class WADA Anti-Doping Classification.
Foods that you MAY eat include:
Pregnancy Category C Risk cannot be ruled out.
Availability Rx Prescription only.
an antidepressant - citalopram, desvenlaine, duloxetine, escitalopram, fluvoxamine, levomilnacipran, milnacipran, mirtazapine, nefazodone, paroxetine, venlaine, vilazodone, vortioxetine, and others; or.
over-the-counter supplements or cough and cold medicines that contain tyramine;
dangerously high blood pressure - severe headache, blurred vision, pounding in your neck or ears, anxiety, nausea, vomiting, severe chest pain, shortness of breath, pounding heartbeats, or seizure (convulsions).
Common Eldepryl side effects may include: dizziness;
See also: Dosage Information (in more detail).
After you stop taking Eldepryl, you must wait at least 14 days before taking any of the medications listed above.
While taking Eldepryl, do not drink alcohol or eat foods that are high in tyramine, listed in the "What should I avoid while using Eldepryl?" section of this leaflet.