Sertraline is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It was.. The U.S. patent for Zoloft expired in 2006, and sertraline is now available in generic form and is marketed under many brand names worldwide.
Cognitive behavioral therapy alone was superior to sertraline in both adults and children; however, the best results were achieved using a combination of these treatments. Sertraline may be useful for the treatment of OCD co-morbid with Tourette syndrome.
As with most other SSRIs its toxicity in overdose is considered relatively low. Acute overdosage is often manifested by emesis, lethargy, ataxia, tachycardia and seizures. Plasma, serum or blood concentrations of sertraline and norsertraline, its major active metabolite, may be measured to confirm a diagnosis of poisoning in hospitalized patients or to aid in the medicolegal investigation of fatalities.
Its chief active metabolite is norsertraline ( N - desmethylsertraline ) which is significantly less biologically active than its parent compound.
Despite being a more potent dopamine reuptake inhibitor than bupropion, it is still a much more potent inhibitor of serotonin reuptake — it is about 60 times more potent at inhibiting serotonin reuptake than it is at inhibiting dopamine reuptake.
ZOLOFT contains sertraline hydrochloride, an SSRI. Sertraline hydrochloride has a molecular weight of 342.7 and has the following chemical.
In 281 pediatric patients treated with ZOLOFT in placebo-controlled studies, the overall profile of adverse reactions was generally similar to that seen in adult studies. Adverse reactions that do not appear in Table 3 (most common adverse reactions in adults) yet were reported in at least 2% of pediatric patients and at a rate of at least twice the placebo rate include fever, hyperkinesia, urinary incontinence, aggression, epistaxis, purpura, arthralgia, decreased weight, muscle twitching, and anxiety.
False-positive test results may be expected for several days following discontinuation of ZOLOFT.
Zoloft (sertraline) is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Zoloft is used to treat depression, obsessive-compulsive disorder, panic disorder, anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual.
Store at room temperature away from moisture and heat.
6 to 12 years: Initial dose: 25 mg orally once a day Maintenance dose: 25 to 200 mg orally once a day 13 to 17 years: Initial dose: 50 mg orally once a day Maintenance dose: 50 to 200 mg orally once a day Comments: -The dose may be increased at intervals of at least one week. -The potential risks versus clinical need should be assessed prior to using this drug in children and adolescents.
sleep problems (insomnia); or.
manic episodes - racing thoughts, increased energy, unusual risk-taking behavior, extreme happiness, being irritable or talkative.
Stay alert to changes in your mood or symptoms.
Sertraline is used to treat depression, panic attacks, obsessive compulsive disorder, post-traumatic stress disorder, social anxiety disorder (social phobia), and a severe form of premenstrual syndrome (premenstrual dysphoric disorder). How to use Zoloft. Treatment by Condition.
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To help you remember, take it at the same time each day. Follow your doctor's instructions carefully. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Take this medication regularly to get the most benefit from it. The dosage is based on your medical condition and response to treatment.
GENERIC NAME(S): Sertraline. Sign up to receive WebMD's award-winning content delivered to your inbox.
Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.
With over 20 years of experience, ZOLOFT is part of the valued heritage of Pfizer. §ZOLOFT is also available in 25 mg (light green tablet) and 100 mg (light.
l your doctor immediay if you:
Patients should always ask their doctors for medical advice about adverse events.
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Do not take ZOLOFT if you:
It is also approved to treat Obsessive Compulsive Disorder (OCD) in children and adolescents aged 6-17 years. ZOLOFT is a prescription medication for the treatment, in adults, of Major Depressive Disorder (MDD), Obsessive-Compulsive Disorder (OCD), Panic Disorder, Posttraumatic Stress Disorder (PTSD), Premenstrual Dysphoric Disorder (PMDD), and Social Anxiety Disorder.
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