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Grapefruit and metoprolol



Interactions of grapefruit juice and cardiovascular medications A

6.17.2017 | Jennifer Bargeman

Recently, drug interactions with grapefruit juice (GFJ) have received considerable attention from basic scientists, physicians, industry and drug regulatory.

Lown and colleagues ( 30 ) found that repeated ingestion of GFJ caused a reduction in the amount of enterocyte CYP 450 3A4 isoenzymes in all human subjects enrolled in their study. The reduction in intestinal concentrations of CYP 450 3A4 enzymes was localized to this tissue because no significant decreases were observed in colonic and hepatic tissue ( 30 ). Recent work has suggested that the inhibitory action of GFJ is due to the downregulation of CYP 450 3A4 enzymes.

The exact constituent(s) of GFJ responsible for the inhibitory activities of CYP 450 3A4 and P-gp have not yet been conclusively identified.

Foods to Avoid When Taking Metoprolol Tartrate Oral

3.14.2017 | Logan Miers

Should I avoid certain foods while taking Metoprolol Tartrate? metoprolol tartrate may interact with the following foods: A change in your diet, medicine, or dosage may be necessary.

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A change in your diet, medicine, or dosage may be necessary. Promptly consult your doctor or pharmacist.

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A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Grapefruit Juice & Beta Blockers

12.23.2017 | Jennifer Bargeman
Grapefruit and metoprolol

Although grapefruit juice interacts with many Beta blockers include the drugs sotalol, propranolol and metoprolol, also known as Betapace.

Beta blockers include the drugs sotalol, propranolol and metoprolol, also known as Betapace, Inderal and Lopressor. These drugs can be used to treat high blood pressure and other conditions. Alcohol should also be avoided, since it can reduce the effects of beta blockers. People taking beta blockers should avoid foods with caffeine, over-the-counter cough and cold medicines, antacids with aluminum, and antihistamines.

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Grapefruit juice can interfere with how the body breaks down and eliminates medications. Many medications are broken down by the liver using an enzyme called cytochrome P450, which is inhibited by grapefruit juice. However, grapefruit juice does not interfere with the metabolism of beta blockers. Consequently, grapefruit juice can increase the levels of many drugs in the body, including several cholesterol-lowering statins.

However, because beta blockers can be affected by some foods and over-the-counter medications, if you are taking beta blockers you should talk to your doctor about food and drug interactions. The effects of some medications can be increased or decreased when they are taken with certain foods. Although grapefruit juice interacts with many medications, it does not affect beta blockers.

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Is it OK to drink Grapefruit juice while taking Metoprolol?

11.22.2017 | Jennifer Bargeman
Grapefruit and metoprolol

Yes, it is fine to take grapefruit juice with metoprolol. There are no known interactions between them.

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Posted 30 May 2017 • 1 answer.

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Posted 18 Feb 2016 • 1 answer.

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provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Data sources include Micromedex (updated June 2nd, 2017), Cerner Multum (updated June 5th, 2017), Wolters Kluwer (updated June 6th, 2017) and others. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. To view content sources and attributions, please refer to our editorial policy.

/food-interactions/metoprolol.html. Yes, it is fine to take grapefruit juice with metoprolol. There are no known interactions between them.

Posted 25 Jan 2014 • 1 answer.

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Posted 24 Feb 2015 • 1 answer.

Will eating grapefruit affect taking metoprolol tartrate?

10.21.2017 | Logan Miers
Grapefruit and metoprolol

Theoretically there should be no interaction between metoprolol and grapefruit or it's juice.

The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices.

Posted 16 Jul 2016 • 1 answer.

Posted 10 Oct 2015 • 2 answers.

Data sources include Micromedex (updated June 2nd, 2017), Cerner Multum (updated June 5th, 2017), Wolters Kluwer (updated June 6th, 2017) and others. To view content sources and attributions, please refer to our editorial policy. provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.

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Theoretically there should be no interaction between metoprolol and grapefruit or it's juice. /food-interactions/metoprolol.html.

Posted 28 Oct 2010 • 1 answer.

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