7.Achamallah NS. Visual hallucinations after combining fluoxetine and dextromethorphan. Am J Psychiatry 1992 Oct;149(10):1406.
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Your antidepressant may cause your body to process dextromethorphan more slowly. In addition, both medicines can increase the level of serotonin in your body.
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Do not start, stop, or change the dosage of any medicine before checking with them first. Make sure your healthcare professional (e.g.doctor or pharmacist) know that you are taking these medicines together. Do not take more than the recommended amount of dextromethorphan.If you experience muscle twitching, tremors, shivering or stiffness, fever, heavy sweating, heart palpitations, restlessness, confusion, agitation, trouble with coordination, or severe diarrhea contact your doctor right away.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it.
4.Sager JE, Lutz JD, Foti RS, Davis C, Kunze KL, Isoherranen N. Clin Pharmacol Ther 2014 Jun;95(6):653-62. Fluoxetine- and norfluoxetine-mediated complex drug-drug interactions: in vitro to in vivo correlation of effects on CYP2D6, CYP2C19, and CYP3A4.
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The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals.
The serotonin syndrome. N Engl J Med 2005 Mar 17; 352(11):1112-20. 5.Boyer EW, Shannon M.
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1.Schoedel KA, Pope LE, Sellers EM. Randomized open-label drug-drug interaction trial of dextromethorphan/quinidine and paroxetine in healthy volunteers. Clin Drug Investig 2012 Mar 1;32(3):157-69.
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Apotex Technologies January, 2017. 2.Paxil (paroxetine hydrochloride) US prescribing information.
Gen Hosp Psychiatry 2006 Jan-Feb; 28(1):78-80. A case of serotonin syndrome precipitated by abuse of the anticough remedy dextromethorphan in a bipolar patient treated with fluoxetine and lithium. 6.Navarro A, Perry C, Bobo WV.
Eli Lilly and Company October, 2014. 3.Prozac (fluoxetine hydrochloride) US prescribing information.
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You could have worsening of usual side effects such as dizziness, headache, or nausea.High serotonin levels may cause changes in body temperature, blood pressure, muscle movements and mood, leading to a medical condition called Serotonin Syndrome. Serotonin Syndrome may be very serious or rarely life threatening.
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These medicines may cause some risk when taken together. doctor or pharmacist) for more information. Moderate. Contact your healthcare professional (e.g.
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The serotonin syndrome associated with paroxetine, an over-the-counter cold remedy, and vascular disease. Am J Emerg Med 1994 Nov;12(6):642-4. 8.Skop BP, Finkelstein JA, Mareth TR, Magoon MR, Brown TM.
Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.Mucinex d drug interactions