Increasingly, however, studies and clinicians are warning about the serious side effects of long-term use of PPIs, which can range from colon.
DGL, which usually is taken within 20 minutes of a meal, is a demulcent — it helps protect the esophagus from acid reflux by coating the esophageal lining.
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Andrew Chan, MD, a gastroenterologist at Massachusetts General Hospital, says that in general, most of the harmful side effects of PPIs are linked to higher doses and prolonged use of the drugs.
Between July 2013 and June 2014, Nexium — “the Purple Pill,” as the ads called it — was the 3rd most prescribed drug with 18,656,464 prescriptions written.
Inhibitory effect of lenvatinib and paclitaxel on the proliferation of ATC cells. Cells were treated with the indicated concentrations of lenvatinib (A) and paclitaxel.
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A SM-TN is seen in the middle of the picture. e) U937 cells treated with 35 nM SMTN.The nanowires are too small to see at this magnification, but their effect on the cells is clearly visible. Scale bar = 10 mm. Microscope image (406) magnification of U937 cells after exposure to SM-TNs. b) U937 cells treated with 200 nM, and 35 nM ODS empty shells. d) U937 cells treated with 200 nM SM-TN. a) Untreated U937 cells. c) U937 cells treated with microcrystalline (free) Taxol prepared by sonicating Taxol in 20%H3PO4/0.8% SDS solution.
Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
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Yousef AA(1), Salem HA(2), Moustafa MZ(2). assessment, and onset of postoperative pain, sedation score, and side effects were recorded.
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Combined spinal–epidural anesthesia; Dexmedetomidine.
Combined spinal-epidural anesthesia is commonly used for elective cesarean section. Our study aimed to evaluate the effect of adding dexmedetomidine to epidural bupivacaine and fentanyl in patients undergoing elective cesarean section using combined spinal-epidural anesthesia.
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The addition of mini-dose epidural dexmedetomidine 0.5 µg/kg as a single injection to bupivacaine fentanyl in women undergoing elective cesarean section with combined spinal-epidural anesthesia improved intraoperative conditions and the quality of postoperative analgesia.
Eighty healthy women at term were randomly assigned to two groups: a control group (n = 40; "Bup/Fen group") received combined spinal-epidural anesthesia with intrathecal hyperbaric bupivacaine 5 mg and an epidural mixture of 10 mL plain bupivacaine 0.25 % and fentanyl 50 μg, whereas the study group (n = 40; "Dex/Bup/Fen group") received 1 mL epidural dexmedetomidine 0.5 µg/kg in addition. The quality of surgical anesthesia, incidences of hypotension and bradycardia, APGAR scores, intraoperative pain assessment, and onset of postoperative pain, sedation score, and side effects were recorded. The primary outcome measure was the difference between the groups in the supplementary fentanyl analgesic required.
There was no statistically significant difference between the groups regarding block characteristics. There was no statistically significant difference between the groups regarding sedation score or the incidences of hypotension, nausea and vomiting, dizziness, and pruritus. Significantly less intraoperative and postoperative fentanyl were required by the Dex/Bup/Fen group (P = 0.015 and P = 0.0011, respectively).
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