Benzodiazepines are frequently prescribed in patients with Alzheimer's disease. Unfortunay, studies evaluating their benefits and risks in.
In summary, numerous studies have studied the effect of BZD in the healthy elderly and dementia patients, but results are inconsistent and allow no valid recommendation for the appropriate usage of BZD in patients with AD. Furthermore, studies are often limited by an insufficient description of the study population and fail to provide a critical look deeper into specific substances, dosages, and indications.
Studies were excluded in case of: (1) missing information regarding applied diagnostic procedure of dementia, (2) dementia was diagnosed based on measures of primary sociobiological functions (Katz-criteria) ( Katz and Akpom, 1976 ), or (3) detection of symptoms of psychological distress, not fulfilling the above mentioned diagnostic criteria of dementia (eg, Helmes et al., 1987 ).
Wetzels et al.
Several studies have shown that benzodiazepine use could be one of these.5. During the study period, 894 people with Alzheimer's disease.
52 Socioeconomic and educational levels have been shown to be inversely correlated with the risk of presenting with dementia, 31 53 54 and thus lack of adjustment for these factors could results in bias. 51 The effect of not adjusting for these factors was likely to be conservative as benzodiazepine use is thought to be higher in regular wine and alcohol consumers. Their association with benzodiazepine use, however, remains unclear as it has been reported as absent, 44 positive, 55 or negative. The RAMQ database does not contain information on socioeconomic status, education level, smoking habits, or alcohol consumption.
Study adds to evidence for link between benzodiazepines and adverse respiratory effects in people with Alzheimer's, and suggests that risk of.
6 MAR 2017 17:55.
There was no statistically increased risk of taking Z-drugs in the analysis of 3,269 patients and case-matched controls, but the study did not directly compare the drugs with benzodiazepines.
Rosa Sancho, head of research at Alzheimer’s Research UK, says: “Benzodiazepines can be given to people with Alzheimer’s to help calm very aggressive behaviour, but their use must be carefully weighed up against the risk of side effects for each individual.
She has also worked for Nursing Times, the European Heart Journal, Chemist and Druggist, OTC, and Pregnancy and Birth magazine among others.
Past research has linked benzodiazepines - drugs used to treat risk for dementia or Alzheimer's than those with lower benzodiazepine use.
Benzodiazepines are a class of drugs that increase the level of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain, producing sedative, anti-convulsant, anti-anxiety, hypnotic and muscle relaxant effects.
However, Gray and colleagues note that research assessing benzodiazepine use in older adults has been conflicting, with some studies finding no link with dementia.
Additional source: NIH news release, accessed 2 February 2016.
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A 2012 study reported by Medical News Today, for example, suggested adults aged 65 and older are 50% more likely to develop dementia within 15 years of using benzodiazepines, while a more recent study suggested benzodiazepine use for at least 3 months increases older adults' risk of Alzheimer's disease by 51%.
Benzodiazepines, commonly used by older adults to manage sleep, anxiety the risk of dementia or hasten cognitive decline, study findings show. no more likely than non-users to develop dementia or Alzheimer's disease.
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But they add that “given the mixed evidence regarding benzodiazepines and risk of dementia and that these drugs are associated with many adverse events, healthcare providers are still advised to avoid benzodiazepines in older adults to prevent important adverse health outcomes, withdrawal, and dependence.”
“Overall, our pattern of findings does not support the theory that cumulative benzodiazepine use at the levels observed in our population is causally related to an increased risk for dementia or cognitive decline”, say Gray and colleagues.
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