Tetracyclines are broad-spectrum antibiotics whose general usefulness has been reduced with Usage during the first 12 weeks of pregnancy does not appear to increase the risk of any major birth defects. There may be a small increased risk.
In tetracycline preparation, stability must be considered in order to avoid formation of toxic epi-anhydrotetracyclines.
Tetracycline derivatives are currently being investigated for the treatment of certain inflammatory disorders.
They may have a role in reducing the duration and severity of cholera, although drug-resistance is mounting and their effect on overall mortality is questioned.
There may be a small increased risk for minor birth defects such as an inguinal hernia, but the number of reports is too small to be sure if there actually is any risk.
It is mainly during this time that some medicines are known to cause birth defects. A baby’s body and most internal organs are formed during the first 12 weeks of pregnancy.
It is therefore possible that taking certain medicines at any stage of pregnancy could have a lasting effect on a child’s learning or behaviour. A baby’s brain continues to develop right up until the end of pregnancy.
New information is continually becoming available. Whilst every effort will be made to ensure that this information is accurate and up to date at the time of publication, we cannot cover every eventuality and the information providers cannot be held responsible for any adverse outcomes following decisions made on the basis of this information.
Tetracycline is not often used during pregnancy, particularly in the second or third trimesters, as use during this period is known to cause a baby's milk teeth to be permanently stained and discoloured when they come through after birth.
If you are on regular medication you should discuss these effects with your doctor/health care team before becoming pregnant. There are, however, some medicines that can harm a baby’s normal development. Most medicines used by the mother will cross the placenta and reach the baby. Sometimes this may have beneficial effects for the baby. How a medicine affects a baby may depend on the stage of pregnancy when the medicine is taken.
Our bumps leaflets are written to provide you with a summary of what is known about use of a specific medicine in pregnancy so that you can decide together with your health care provider what is best for you and your baby.
Exposure to tetracyclines in early pregnancy has not been convincingly associated with any specific malformation, however data for some tetracyclines are.
This document is regularly reviewed and updated. The summaries of these monographs are openly available on UKTIS.org. Only use full UKTIS monographs downloaded directly from TOXBASE.org to be sure you are using the most up-to-date version.
A corresponding patient information leaflet on tetracycline use in pregnancy is available at.
Disclaimer: Every effort has been made to ensure that this monograph was accurate and up-to-date at the time of writing, however it cannot cover every eventuality and the information providers cannot be held responsible for any adverse outcomes of the measures recommended.
Advice and warnings for the use of Tetracycline during pregnancy. FDA Pregnancy Category D - Positive evidence of risk.
Approval History Calendar Drug history at FDA More FDA updates.
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Pregnancy Category D Positive evidence of risk.
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CSA Schedule N Not a controlled drug.
The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.