Trazodone has been shown to be a good option for treatment of the elderly with Key words: sleep, dementia, Alzheimer's disease, trazodone, antidepressant.
The use of antidepressants with hypnotic actions, such as trazodone, plays an important role in these cases. In the one-year period comprising the study, 68 (38.2%) of the 178 had sleep disorders. Trazodone has been shown to be a good option for treatment of the elderly with dementia and associated SD. Sleep disorders (SD) in patients with dementia are very common in clinical practice. The aim of this study is to present a profile of the use of trazodone in demented patients with SD, as well as a review of trazodone hydrochloride in SD.
In the elderly, insomnia is complex and often difficult to relieve because the Sleep apnea also should be considered in the differential assessment. A low dosage of a sedating antidepressant, such as trazodone (Desyrel).
Conditioned insomnia occurs when the act of going to bed triggers anxiety and the inability to go to sleep. In other words, the patient has been inadvertently trained to stay awake at bedtime. A clue to this disorder may be the patient's ability to readily fall asleep at times when he or she is not focusing on obtaining slumber (i.e., unscheduled naps).
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New medications (see Table 2 ).
Eat meals on a regular schedule.
Don't read, watch evision, eat or do other activities in bed.
Elderly patients may differ from younger patients in the presentation of symptoms These risk factors included grief, sleep problems, disability, previous. If a patient cannot tolerate an SSRI or SNRI, however, trazodone may.
Monoamine oxidase inhibitors (MAOIs) work by inhibiting monoamine oxidase enzyme, which increases the availability of monoamines causing increased concentration of neurotransmitters such as epinephrine, norepinephrine, and dopamine.23 Adverse effects of this class (sleep disturbance, orthostatic hypotension, sexual dysfunction, weight gain) detract from their use as an antidepressant in the elderly population. Some studies have shown efficacy superior to other antidepressant agents in the treatment of atypical depression, mixed anxiety-depressive states, and panic disorder; however, few studies have included an elderly population of patients.25 Selegiline is available as a transdermal patch, which may provide a convenient dosage form for some elderly patients.
Physical discomfort such as hunger, constipation and sleep The serotonergic antidepressant trazodone (Desyrel) has been used to treat.
J Geriatr Psychiatry Neurol 1(4):226-230. It is the symptoms of agitation such as uncooperativeness with necessary care, motoric hyperactivity, verbal abuse and disinhibition that are the most stressful aspect of caring for the demented person. Ayd FJ Jr (1995), Lexicon of Psychiatry, Neurology and the Neurosciences. Valproate may be as effective and a safer treatment for the behavioral complications of dementia, particularly of the Alzheimer's type. The benzodiazepines stay in the body a short period of time, and can be ordered on an as-needed basis.
People with dementia frequently suffer from sleep disturbances. Participants in the melatonin and trazodone trials almost all had moderate to.
These behaviours can also be difficult for care-home staff to manage well. Can medicines help?. These behaviours cause a lot of stress to carers, and may be associated with earlier admission to institutional care for people with dementia.
We found six RCTs eligible for inclusion for three drugs: melatonin (222 participants, four studies, but only two yielded data on our primary sleep outcomes suitable for meta-analysis ), trazodone (30 participants, one study ), and ramelteon (74 participants, one study, no peer-reviewed publication, limited information available).
To assess the effects, including common adverse effects, of any drug treatment versus placebo for sleep disorders in people with dementia, through identification and analysis of all relevant randomised controlled trials ( RCTs ).
We included RCTs that compared a drug with placebo, and that had the primary aim of improving sleep in people with dementia who had an identified sleep disturbance at baseline.