DESCRIPTION. LEUKERAN (chlorambucil) was first synthesized by Everett et al. It is a bifunctional alkylating agent of the nitrogen mustard.
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The dose of chlorambucil should be decreased if leukocyte or plaet counts fall below normal values and should be discontinued for more severe depression. While it is not necessary to discontinue chlorambucil at the first evidence of a fall in neutrophil count, it must be remembered that the fall may continue for 10 days after the last dose, and that as the total dose approaches 6.5 mg/kg, there is a risk of causing irreversible bone marrow damage.
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Gastrointestinal disturbances such as nausea and vomiting, diarrhea, and oral ulceration occur infrequently.
It is considered dangerous to allow a patient to go more than 2 weeks without hematological and clinical examination during treatment.
Find patient medical information for Leukeran Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
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Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets.
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Physician reviewed Leukeran patient information - includes Leukeran description, dosage and directions.
Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.
You should not use chlorambucil if you are allergic to it, or if you have received chlorambucil in the past without successful treatment of your condition.
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easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
Talk to your doctor about your specific risk.
Easy to read patient leaflet for Leukeran. Includes indications, proper use, special instructions, precautions, and possible side effects.
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Leukeran is an alkylating agent. It works by stopping the growth of certain cancer cells.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); absence of menstrual period; agitation; burning, numbness, or tingling; confusion; dark, tarry, or bloody stools; decreased coordination; fever, chills, or persistent cough or sore throat; hallucinations; limp muscles or inability to move; muscle twitching; nausea; red, swollen, blistered, or peeling skin; seizures; shortness of breath or difficulty breathing; sores in the mouth or on the lips; symptoms of liver problems (eg, dark urine, pale stools, persistent loss of appetite, stomach pain, yellowing of the skin or eyes); tremors; unusual bruising or bleeding; unusual lumps or growths; unusual tiredness or weakness; vomiting.
Some MEDICINES MAY INTERACT with Leukeran.
Drug Type: Leukeran is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. Used to treat chronic lymphocytic leukemia (CLL), Hodgkin's disease, non-Hodgkin's lymphoma, breast, ovarian and testicular cancer, Waldenstrom's macroglobulinemia, thrombocythemia.
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However, you should always inform your health care provider if you experience any unusual symptoms. Not all side effects are listed above, some that are rare (occurring in less than 10% of patients) are not listed here.
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The following side effects are rare for patients receiving Leukeran, discuss any concerns regarding these with your health care professional:
Always inform your health care provider if you experience any unusual symptoms.
The "normal" cells most commonly affected by chemotherapy are the blood cells, the cells in the mouth, stomach and bowel, and the hair follicles; resulting in low blood counts, mouth sores, nausea, diarrhea, and/or hair loss.