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Zolpidem


Udocheals.orgZolpidem drug
6.17.2017 | Jessica MacAdam
Zolpidem drug
Zolpidem

92.5 ± 0.1% (independent of concentration between 40 and 790 ng/mL).

Unlike the benzodiazepines, which non-selectively interact with all three alpha-receptor subtypes, Zolpidem preferentially binds to the alpha-1 receptor. Zolpidem modulates the alpha-subunit, known as the benzodiazepine receptor, within the GABA A receptor chloride channel macromolecular complex.

Zolpidem is converted to inactive metabolites in the liver.

Zolpidem is rapidly absorbed from the GI tract.

Markus Sauter, "Process for preparing zolpidem." U.S. Patent US, issued December 05, 2002.

For the short-term treatment of insomnia.

It is classified as an imidazopyridine. It works quickly (usually within 15 minutes) and has a short half-life (2-3 hours). As an anticonvulsant and muscle relaxant, the beneficial effects start to emerge at 10 and 20 times the dose required for sedation, respectively. For that reason, it has never been approved for either muscle relaxation or seizure prevention. Zolpidem is a prescription short-acting nonbenzodiazepine hypnotic that potentiates gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, by binding to benzodiazepine receptors which are located on the gamma-aminobutyric acid receptors. Zolpidem is used for the short-term treatment of insomnia. Recently, zolpidem has been cited in various medical reports mainly in the United Kingdom as waking persistent vegetative state (PVS) patients, and dramatically improving the conditions of people with brain injuries.

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Symptoms of overdose include impairment of consciousness ranging from somnolence to light coma. Oral (male rat) LD 50 = 695 mg/kg.

Zolpidem tartrate tablets are converted to inactive metabolites that are eliminated primarily by renal excretion. 2.6 hours.

The (alpha1) receptor is found primarily on the Lamina IV of the sensorimotor cortical regions, substantia nigra (pars reticulata), cerebellum molecular layer, olfactory bulb, ventral thalamic complex, pons, inferior colliculus, and globus pallidus. Zolpidem is a sedative or hypnotic agent with a chemical structure unrelated to benzodiazepines, barbiturates, or other drugs with known hypnotic properties. It interacts with a GABA-BZ receptor complex and shares some of the pharmacological properties of the benzodiazepines. In contrast to the benzodiazepines, which non-selectively bind to and activate all three alpha receptor subtypes, zolpidem in vitro binds the (alpha1) receptor preferentially.

Zolpidem drug