However, the drug might exert nuanced effects on anxiety and depression. Because of its pharmacological actions in the brain, Ambien rarely--if ever--gets used as an anxiety-reducing medication. Doctors typically prescribe Ambien, also known as zolpidem tartrate, for the short-term treatment of insomnia.
Depression often co-occurs with anxiety. Of note, the relationship between sleep and depression is a complicated one, and the degree to which insomnia itself contributes to anxiety and depression is currently under study. According to Dr. Daniel Kripke at the Scripps Clinic Sleep Center, people who regularly use Ambien and other hypnotic drugs might actually be at greater risk for developing depression than those who do not.
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Benzodiazepines like Xanax increase the effects of GABA, which is a signal normally used by cells to reduce excitability in brain circuits. Like Xanax, Ambien binds benzodiazepine receptors in the brain and drives GABA chemical signaling. However, while Xanax tends to bind all benzodiazepine receptors, Ambien binds only certain subpopulations. According to Cynthia Kirkwood and other pharmacy researchers at Virginia Commonwealth University, this specificity allows Ambien to selectively act as a sedative drug without also acting as a seizure- or anxiety-reducing medication. Therapeutically, these drugs decrease the incidence of seizures in people with epilepsy and decrease subjective feelings of anxiety in those suffering from generalized anxiety or post-traumatic stress disorder.
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Sudden discontinuation of Ambien can cause serious withdrawal symptoms involving heightened anxiety and restlessness--effects antithetical to benzodiazepine drugs. People taking Ambien should consult their doctors about how to taper their Ambien prescription over time to avoid drug withdrawal.
Ambien's unpleasant side effects can include next-day drowsiness, nausea, impaired driving and poor concentration at work. People taking Ambien might experience anxiety as a result of the drug's side effects, not because of its direct actions.
Sanofi-Aventis, the pharmaceutical manufacturer of Ambien, cautions Ambien users that they might experience abnormal increases in impulsivity or become "more outgoing" during treatment. In a paper published in "Psychopharmacology," Dr. Activity in the amygdala positively correlates with the expression of fear-related behavior. Estibaliz Arce and her colleagues at the University of California San Diego suggest that the anxiety-reducing properties of typical benzodiazepines might stem from their ability to reduce the excitability of an almond-shaped structure in the brain called the amygdala. Together, this information points to the possibility that Ambien might have some limited anxiety-reducing effects. As such, when amygdala excitability drops, people will show more risk-taking and impulsivity.Ambien depression