See also Warning section.
Subscribe to the Men's Health newsletter for the latest on disease prevention, fitness, sex, nutrition, and more from WebMD.
Symptoms of overdose may include: severe nausea / vomiting, unusual vaginal bleeding. Otherwise, call a poison control center right away. US residents can call their local poison control center at. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Canada residents can call a provincial poison control center.
Estrogens and progestins should not be used to prevent heart disease or dementia. Discuss the risks and benefits of hormone treatment with your doctor. Estrogens, either used alone or with a progestin, have rarely caused very serious side effects.
Before using this medication, l your doctor or pharmacist your medical history, especially of: vaginal bleeding of unknown cause, certain cancers (such as breast cancer, cancer of the uterus/ ovaries ), blood clots, stroke, heart disease (such as heart attack ), liver disease, kidney disease, family medical history (especially breast lumps, cancer, blood clots, angioedema), blood clotting disorders (such as protein C or protein S deficiency), high blood pressure, diabetes, high blood cholesterol / triglyceride levels, obesity, lupus, underactive thyroid ( hypothyroidism ), mineral imbalance (low or high level of calcium in the blood), a certain hormone problem ( hypoparathyroidism ), uterus problems (such as fibroids, endometriosis ), gallbladder disease, asthma, seizures, migraine headaches, a certain blood disorder ( porphyria ), mental/ mood disorders (such as dementia, depression ).
Take this medication by mouth with or without food as directed by your doctor, usually once daily. You may take it with food or right after a meal to prevent stomach upset.
WebMD does not provide medical advice, diagnosis or treatment. See additional information.
The dosage is based on your medical condition and response to treatment.
If you notice other effects not listed above, contact your doctor or pharmacist. This is not a complete list of possible side effects.
Our pill identification tool will display pictures that you can compare to your pill. Enter the shape, color, or imprint of your prescription or OTC drug.
If you are using this medication to treat symptoms only in and around the vagina, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected.
Having trouble identifying your pills?
However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching /swelling (especially of the face/ tongue /throat), severe dizziness, trouble breathing. A very serious allergic reaction to this drug is rare.
l your doctor right away if you have any serious side effects, including: mental/mood changes (such as depression, memory loss ), breast lumps, unusual vaginal bleeding (such as spotting, breakthrough bleeding, prolonged/recurrent bleeding), increased or new vaginal irritation / itching /odor/discharge, severe stomach / abdominal pain, persistent nausea / vomiting, yellowing eyes / skin, dark urine, swelling hands/ ankles /feet, increased thirst/urination.
If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule. If you miss a dose, take it as soon as you remember. Do not double the dose to catch up.
Search by name or medical condition. Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements.
These medications should be considered for use before estrogen/progestin treatment. However, there are other medications (such as raloxifene, bisphosphonates including alendronate ) that are also effective in preventing bone loss and may be safer. This medication may also be used by women after menopause to prevent bone loss ( osteoporosis ).
Do not store in the bathroom. Store at room temperature away from light and moisture. Keep all medications away from children and pets.
l your doctor if you just had or will be having surgery, or if you will be confined to a chair or bed for a long time (such as a long plane flight). You may need to stop this medication for a time or take special precautions. These conditions increase your risk of getting blood clots, especially if you are using an estrogen product.
Subscribe to the WebMD Daily, and you'll get today's top health news and trending topics, and the latest and best information from WebMD.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else.
If any of these effects persist or worsen, l your doctor or pharmacist promptly. Stomach upset, nausea / vomiting, bloating, breast tenderness, headache, or weight changes may occur.
Subscribe to free WebMD newsletters.
Follow your doctor's instructions for examining your own breasts, and report any lumps right away. You should have regular complete physical exams (for example, once a year) which include laboratory and medical tests (such as blood pressure, breast exam/ mammogram, pelvic exam, pap smear ) to monitor your progress and check for side effects. Keep all regular medical and laboratory appointments. Consult your doctor for more details.
Many people using this medication do not have serious side effects. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Drug interactions may change how your medications work or increase your risk for serious side effects. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
You may report side effects to Health Canada at. In Canada - Call your doctor for medical advice about side effects.
It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness ). Women who have had their uterus removed do not need the progestin and therefore should not use this combination medication. This medication contains 2 female hormones: an estrogen (such as conjugated estrogen, estradiol ) and a progestin (such as medroxyprogesterone, norethindrone, norgestimate ). These symptoms are caused by the body making less estrogen. The progestin in this medication helps to reduce the risk of cancer of the uterus which can be caused by using estrogen.
In postmenopausal women, estrogen when used with a progestin can increase the risk of heart disease (such as heart attacks ), stroke, serious blood clots in the lungs /legs, dementia, and cancer of the breast / ovaries.
Connect with people like you, and get expert guidance on living a healthy life.
This medication may interfere with certain laboratory tests (including metyrapone test), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.
l your doctor if your condition does not improve or if it worsens.
It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you. Talk to health experts and other people like you in WebMD's Communities.
In the US.
Lifestyle changes that may help reduce hot flashes include stopping smoking, dressing lightly or in layers, avoiding/limiting certain foods (spicy foods, caffeine, alcohol), reducing stress, and exercising regularly.
If you have any questions, ask your doctor or pharmacist. Read the Patient Information Leaflet if available from your pharmacist before you start using this medication and each time you get a refill.
If you become pregnant or think you may be pregnant, l your doctor right away. This medication must not be used during pregnancy.
Do not share this medication with others.
Read expert perspectives on popular health topics.
To help you remember, take it at the same time each day. Follow your dosing schedule carefully. Take this medication regularly to get the most benefit from it. Do not increase your dose or take this medication more often or for a longer time than directed.
Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.Information last revised November 2016. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. 2016 First Databank, Inc.
Therefore, this medication should be used at the lowest effective dose and for the shortest amount of time. The risk for serious side effects may depend on the dose of estrogen and the length of time it is used. See also Notes section. If you will be using this medication long-term, you should have regular complete physical exams (for example, once a year) as directed by your doctor. Discuss the use of this medication with your doctor regularly (for example, every 3 to 6 months) to see if you still need to use it.
Drugs & Supplements. See what your medical symptoms could mean, and learn about possible conditions.
Subscribe to the Women's Health newsletter for the latest on disease prevention, fitness, sex, diet, anti-aging, and more from WebMD.
Talk to your pharmacist for more details. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Before taking this medication, l your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
Get medical help right away if you have any serious side effects, including: chest/jaw/left arm pain, unusual sweating, sudden/severe headache, weakness on one side of the body, confusion, slurred speech, sudden vision changes (such as partial/complete blindness), pain/redness/swelling of legs, tingling/weakness/numbness in the arms/legs, trouble breathing, coughing up blood, sudden dizziness / fainting. This medication may rarely cause serious problems from blood clots (such as heart attacks, strokes, deep vein thrombosis, pulmonary embolism ).
This medication passes into breast milk. It may reduce the quality and amount of breast milk produced. Consult your doctor before breast-feeding.
GENERIC NAME(S): Conj Estrog-Medroxyprogest Ace.
Estrogens combined with smoking further increases your risk of stroke, blood clots, high blood pressure, and heart attack, especially in women older than 35. Do not smoke or use tobacco.
Sign up to receive WebMD's award-winning content delivered to your inbox.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
If you are nearsighted or wear contact lenses, you may develop vision problems or trouble wearing your contact lenses. Contact your eye doctor if these problems occur.
With WebMD's Medicine Cabinet, you can check interactions with drugs.
Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.
Lifestyle changes that can help to control or prevent these diseases include reducing stress, eating a low fat /salt diet, losing weight if overweight, exercising regularly, and stopping smoking. Talk to your doctor about lifestyle changes that might benefit you. Preventing or controlling high blood pressure, high cholesterol, and diabetes can help to reduce your chances of heart disease and stroke. Keep your mind active with mental exercises (such as reading, solving crossword puzzles) to help prevent dementia.
Health Concern On Your Mind?
Since you may also need to take calcium and vitamin D supplements and make lifestyle changes, consult your doctor for specific advice. Lifestyle changes that help promote healthy bones include increasing weight -bearing exercise, stopping smoking, limiting alcohol, and eating well-balanced meals that contain adequate calcium and vitamin D.
Some products that may interact with this drug include: aromatase inhibitors (such as anastrozole, exemestane, letrozole ), fulvestrant, ospemifene, raloxifene, tamoxifen, toremifene, tranexamic acid, a certain combination product used to treat chronic hepatitic C (ombitasvir/paritaprevir/ ritonavir /dasabuvir).
Use sunscreen and wear protective clothing when outdoors. This medication may cause blotchy, dark areas on your face and skin (melasma). Avoid tanning booths and sunlamps. Limit your time in the sun. Sunlight may worsen this effect.Prempro