Uses. This medication contains 2 female hormones: an estrogen (such as conjugated estrogen, estradiol) and a progestin (such as medroxyprogesterone, norethindrone, norgestimate). It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness).
See also Warning section.
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Symptoms of overdose may include: severe nausea / vomiting, unusual vaginal bleeding. Otherwise, call a poison control center right away. US residents can call their local poison control center at. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Canada residents can call a provincial poison control center.
Estrogens and progestins should not be used to prevent heart disease or dementia.
Prempro (conjugated estrogens and medroxyprogesterone) is used to treat the symptoms of menopause such as hot flashes and vaginal dryness. Includes.
chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
a history of heart attack, stroke, or blood clot (especially in your lung or your lower body);
Have regular physical exams and mammograms, and self-examine your breasts for lumps on a monthly basis while using this medication.
acne, increased hair growth, loss of scalp hair;
Generic Name: conjugated estrogens and medroxyprogesterone (KON joo GAY ted ES troe jenz and me DOX ee proe JES ter one) Brand Names: Premphase, Prempro.
Approval History Calendar Drug history at FDA.
See also: Side effects (in more detail).
This medication can cause unusual results with certain medical tests.
During the first year of a 2-year clinical trial with postmenopausal women between 40 and 65 years of age (88 percent Caucasian), 989 postmenopausal women received continuous regimens of PREMPRO, and 332 received placebo tablets. Table 2 summarizes adverse reactions that occurred at a rate ≥ 1 percent in at least 1 treatment group.
In a 1-year clinical trial that included 678 postmenopausal women treated with PREMPRO and 351 postmenopausal women treated with PREMPHASE, the following adverse reactions occurred at a rate ≥ 1 percent, see Table 1.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
For pharyngitis, of the 121 events, six events were considered by the investigator causally related to study drug.
Find a comprehensive guide to possible side effects including common and rare side effects when taking Prempro, Premphase (Conjugated Estrogens.
For pharyngitis, of the 121 events, six events were considered by the investigator causally related to study drug. In addition, phargyngitis and sinusitis were reported as two of the more frequent adverse events ( > 5 percent) in the PREMPRO clinical study. For sinusitis, of the 73 events, one event was considered as casually related to study drug.
Prempro therapy consists of a single tablet to be taken orally once daily. Consult your doctor before breast-feeding. l your doctor all medications you are taking.
Prempro is prescription medication used to treat moderate to severe hot flashes and vaginal dryness, burning, and irritation after menopause.
Estrogen plus progestin therapy should not be used for the prevention of cardiovascular disease or dementia.
l your healthcare provider.
Serious, but less common side effects include:
The medication contains a progestin to decrease the chance of getting cancer of the uterus. Do not take this medication if you have had your uterus (womb) removed (hysterectomy). If you do not have a uterus, you do not need a progestin and you should not take Prempro.
Especially l your doctor if you take:. l your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
For more information on this medication choose from the list of selections below.
Estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.
l your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
Call your healthcare provider right away if you get any of the following warning signs or any other unusual symptoms that concern you:
The WHI estrogen plus progestin substudy demonstrated an increased risk of invasive breast cancer.
Do not take Prempro if you:
The WHIMS estrogen-alone ancillary study of WHI reported an increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 5.2 years of treatment with daily CE (0.625 mg)-alone, relative to placebo.